.223 vs 5.56, what’s the freaking difference? You can shoot a .223 out of a 5.56 but you might not want to shoot a 5.56 out of a .223. That’s basically the bottom line but you already knew that, right? Grain, velocity, and other small differences are all discussed in the video below. More Common Questions About Guns and Gun Accessories Why Are Some Magazines Curved? Should You Shoot With Both Eyes Open? How Do You Make A “Cut Shell”?